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  "Description": "Reaction rate dynamics can be retrieved from metabolite\nconcentration time courses. User has to provide corresponding\nstoichiometric matrix but not a regulation model\n(Michaelis-Menten or similar). Instead of solving an ordinary\ndifferential equation (ODE) system describing the evolution of\nconcentrations, we use B-splines to catch the concentration and\nrate dynamics then solve a least square problem on their\ncoefficients with non-negativity (and optionally monotonicity)\nconstraints. Constraints can be also set on initial values of\nconcentration. The package 'dynafluxr' can be used as a library\nbut also as an application with command line interface\ndynafluxr::cli(\"-h\") or graphical user interface\ndynafluxr::gui().",
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